DESCRIPTION

• In silico strain design through determination of optimal genetic intervention strategies.
• In silico estimation of maximum theoretical yields and productivities for biomass and commercial interest products with different culture media through genome-scale metabolic models.
• Culture media design based on metabolic mathematical models.
• In silicostudy of dynamic effects of genetic modifications and metabolic regulation processes on the production of biotechnologically interesting metabolites in batch and fed-batch bioreactors.
• IntEgration of bioreactor and metabolic mathematical models to study the dynamic interactions between cellular metabolism and environmental changes in batch and fed-batch bioreactors.
• In silico drug discovery.