#3208

Aerosols Characterization

PHYSICOCHEMICAL AND BIOPHARMACEUTICAL EVALUATION OF AEROSOLS

DESCRIPTION

Raw materials and products characterization • Geometric and aerodynamic particle size distributions • Dose uniformity • Dissolution • Quantification of components (UV, IR, HPLC, MS, GC, NIR, etc.) • Microscopy • X-ray diffraction • Stability • DSC • TGA • Porosity and BET area • Moisture • aw • Cytotoxicity • Test in inflammation model • in vitro mucoadhesion and permeation • in silico fluidodynamic studies • Others.

AVAILABLE EQUIPMENT

  • Cascade Impactor – Next Generation Impactor (NGI) (COPLEY SCIENTIFIC)
  • Laser diffraction particle size analyzer (Horiba, LA 950-V2)
  • Franz cells
  • Dissolution apparatus (AGILENT, 708 DS)
  • High pressure liquid chromatograph (HPLC) (Waters, 600), High pressure liquid chromatograph (Waters Alliance, e2695)
  • Moisture analyser (Ohaus, M45)
  • Software ANSYS-Fluent
  • Stability chamber
  • Surface area analyzer (Quantachrome, NOVA 1200e)
  • TEM, SEM
  • Others

APPLICATIONS :

Formulations to nebulize | Dry powder inhalers | Pressurized aerosols | Spray nasal formulations | Aerosols for dermal and buccal drug delivery | Spacers and valved holding chambers evaluation |

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